John D. Cook:

The rule of three gives a quick and dirty way to estimate these kinds of probabilities. It says that if you’ve tested N cases and haven’t found what you’re looking for, a reasonable estimate is that the probability is less than 3/N. So in our proofreading example, if you haven’t found any typos in 20 pages, you could estimate that the probability of a page having a typo is less than 15%.